Structure–efficiency relationships of cyclodextrin scavengers in the hydrolytic degradation of organophosphorus compounds

• Sophie Letort,
• Michaël Bosco,
• Benedetta Cornelio,
• Frédérique Brégier,
• Sébastien Daulon,
• Géraldine Gouhier and
• François Estour

Beilstein J. Org. Chem. 2017, 13, 417–427, doi:10.3762/bjoc.13.45

• of the agents. The degradation efficiency was found to be dependent on the relative position of the heterocycle towards the reactive group as well as on the nature of the organophosphorus derivative. Keywords: cyclodextrin; decontamination; enzyme mimic; nerve agents; organophosphorus pesticides

• hydrophobic molecules. In particular, these macromolecular structures display the interesting capability to include organophosphorus pesticides into their cavity [13][14][15][16][17]. However, their intrinsic ability to transform these compounds into low or non-toxic metabolites at physiological pH is weak

• soman and organophosphorus pesticides having an aromatic group were not hydrolyzed with the same efficiency by the scavengers. In fact, this efficiency is highly substrate-dependent and it is difficult to strictly correlate the hydrolysis profiles to the cyclodextrin structures of the prepared

Interactions of cyclodextrins and their derivatives with toxic organophosphorus compounds

• Sophie Letort,
• Sébastien Balieu,
• William Erb,
• Géraldine Gouhier and
• François Estour

Beilstein J. Org. Chem. 2016, 12, 204–228, doi:10.3762/bjoc.12.23

• on the current use of cyclodextrins against organophosphorus compound intoxications. Organophosphorus pesticides and nerve agents play a determinant role in the inhibition of cholinesterases. The cyclic structure of cyclodextrins and their toroidal shape are perfectly suitable to design new chemical

• potential immunogenic risks associated to proteins such as hydrolases [37]. This review focuses on the various aspects of the detoxification process mediated by CD derivatives: (1) the ability of CDs and their derivatives to form inclusion complexes with organophosphorus pesticides and G nerve agents; (2

• guest might weaken the hydration water binding, as revealed in DSC experiments by the lower endothermic fusion peak, specific to a dehydration process. X-ray powder diffraction analysis finally confirmed the complex formation. All these studies proved that organophosphorus pesticides are able to